Design and characterisation of lopinavir nanocrystals for solubility and dissolution enhancement
نویسندگان
چکیده
منابع مشابه
Drug Nanocrystals: Theoretical Background of Solubility Increase and Dissolution Rate Enhancement
Regardless of the administration route, the key factor for the success and reliability of any formulation is drug bioavailability, defined as the rate and extent at which the active drug is absorbed from a pharmaceutical form and becomes available at the site of drug action.1 Although metabolism and physiological factors highly affect drug absorption by living tissues, bioavailability is strong...
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Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility have low dissolution rates and hence suffer from oral bioavailability problems. The poor solubility and poor dissolution rate of poorly water soluble drugs in the aqueous gastro intestinal fluids ...
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15 صفحه اولSolubility and Dissolution Enhancement of Silymarin with Fulvic Acid Carrier
Objective: Solubility is a key parameter as it is one of the main causes for poor bioavailability. The objective was to improve the solubility and dissolution profile of poorly-soluble silymarin with a water-soluble carrier fulvic acid. Materials and methods: Phase solubility studies were carried out for the determination of stoichiometric ratio between silymarin and fulvic acid by Higuchi and ...
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INTRODUCTION Solubility is defined in quantitative terms as the concentration of solute in a saturated solution at a certain temperature and pressure. Qualitatively it is defined as the spontaneous interaction of two or more substances to form a homogenous molecular dispersion. The United State Pharmacopoeia (USP) and national formulary lists the solubility of drug as the number of milliliters ...
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ژورنال
عنوان ژورنال: Pharmaceutical Sciences Asia
سال: 2019
ISSN: 2586-8195,2586-8470
DOI: 10.29090/psa.2019.03.018.0020